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The European “CHASSY” project: putting yeasts to work to produce high value compounds for industrial processes

The Micalis research unit is taking part in a European project to develop the use of yeasts to produce high value compounds for the cosmetic, nutrition, chemical and pharmaceutical sectors.

Detailed look at probe and loop systems of a bioreactor used to grow micro-organisms. © INRA, © Jean-Philippe GUIRAUDIE /jpgphotographie.co
By Christine Jez, translated by Emma Morton Saliou
Updated on 04/05/2018
Published on 01/05/2018

Can little living factories be used to produce high-value ingredients for industrial processes? Such is the goal of the European CHASSY project (Model-based construction and optimisation of versatile chassis yeast strains for production of valuable lipid and aromatic compounds), funded by the Horizon 2020 programme. The project brings together academic and industry partners with the goal of building yeast strains which can be used as platforms to produce high-value oleochemical and aromatic molecules for industrial processes. The consortium uses systems and synthetic biology to remodel three species of yeast suited to specific applications and with optimised metabolic pathways of interest.

The BIMLip team (Biologie Intégrative du Métabolisme Lipidique) and the PAPPSO proteomics platform of the Micalis research unit are taking part in CHASSY, along with nine other industrial and academic partners. Coordination is provided by John Morrissey at University College in Cork, Ireland.  

The BIMLip team is contributing expertise to the CHASSY project to develop generic synthetic biology tools to construct yeast strains tailored to industrial applications and improve their robustness in industrial fermentation conditions. The PAPPSO platform provides all participants with unmarked relative and absolute quantitative proteomic analysis of the three yeast species involved.

The project aims to boost technological innovation in microbial cell factories in the food, fuel, cosmetic and pharmaceutical industries. Some of the resulting products can replace petrochemical and palm oil products.

Download the CHASSY project presentation brochure

Watch the CHASSY project video presentation

Read summaries of CHASSY project publications